George Noutsios

4701 W. Thunderbird Rd.
CLCC 310A1
Phoenix
Asst Research Professor (FSC)
Faculty
WEST Campus
Mailcode
2352
Research Assistant Professor
Post Doctoral Scholars
WEST Campus
Mailcode
2352

Biography

George T. Noutsios was born and raised in Thessaloniki. Greece has a bachelor's degree in chemistry, a master's degree in biochemistry, and a doctorate in biochemistry and molecular biology from the Aristotle University of Thessaloniki. His dissertation focused on the immobilization of antigenic biomolecules in bio-polymeric substrates to detect and diagnose endemic Brucella melitensis biotypes. In 2011 he came to the U.S. to pursue his career in respiratory diseases research. During his postdoctoral work at Penn State Hershey Medical Center (2011-2016), he studied the role of cis-acting elements and trans-acting factors on splicing and translation of the pulmonary surfactant protein A, and he identified 14-3-3 isoforms and microRNAs as translational regulatory molecules in lung diseases. He joined the University of Arizona in 2016, where he was involved in a collaborative effort to unveil the primary mechanisms of chronic sinusitis in upper airway diseases utilizing in vivo and in vitro air-liquid interface models.

Noutsios joined Arizona State University in 2018 as an assistant research professor, where he conducts his own independent research, which is extramurally funded. His focus is to decipher the role of surfactant protein A in upper airway disease and its potential as therapeutic in bacterial sinusitis. At ASU, he has multiple roles: teaching microbiology as a guest lecturer, managing Dean Sandrin's research lab, and participating in a multidisciplinary team that is using molecular biology, environmental microbiology, metaproteomics, genomics, and microbiome approaches to elucidate fundamental questions in human health and disease. Noutsios maintains active collaborative relationships with academic and clinical institutions across the country (PSU, UA, ASU, and Mayo Clinic) to translate basic scientific findings in a laboratory setting into potential treatments for human disease. George enjoys cycling, working out, traveling, trying new cuisines, and craft beer in his spare time.

Fax

602/543-6073

Education

  • Ph.D. Biochemistry, Aristotle University 2009
  • M.S. Biochemistry, Aristotle University 2006
  • B.S. Chemistry (Biochemistry), Aristotle University 2004

Google Scholar

Publications

Full list of publications:

  1. Disease of the lung: allergies, asthma, infection.
    1. Noutsios GT and Sharma S. Chronic Rhinosinusitis in Unified Airway Disease: Surfactant Proteins as Mediators of Respiratory Immunity. Swiss Med Wkly., 2019, 149:w201044.
    2. Noutsios GT, Thorenoor N, Zhang X, Phelps DS, Umstead TM, Durrani F, Floros J. Major Effect of Oxidative Stress on the Male, but not Female, SP-A1 Type II Cell miRNome. Front. Immunol.,10:1514. doi: 10.3389/fimmu.2019.01514.
    3. Noutsios GT and Pantazaki AA. Biomedical Applications of Biopolymers in Airway Disease. Pneumon 2018, 31(1):24-34.
    4. Noutsios GT, Thorenoor N, Zhang X, Phelps DS, Umstead TM, Durrani F, Floros J. SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved. Biol Sex Differ. 2017 4;8(1):37.
    5. Noutsios GT, Willis AL, Ledford JG, and Chang EH. Novel Role of Surfactant Protein A In Bacterial Sinusitis. Int Forum Allergy Rhinol. 2017 Sep;7(9):897-903.
    6. Chang, EH, Willis AL, McCrary HC, Noutsios GT, Le CH, Chiu AG, Mansfield CJ, Reed DR, Brooks SG, Adappa ND, Palmer JN, Cohen NG, Stern DA, Guerra S, Martinez FD. Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis. J Allergy Clin Immunol. 2016 Dec 3. pii: S0091-6749(16)31434-8.
    7. Georgios T Noutsios and Joanna Floros. Childhood Asthma: Causes, Risks, and Protective Factors; a role of innate immunity. Swiss Med Wkly. 2014; 144:w14036.
  2. Surfactant protein interactions
    1. Noutsios GT and Floros J. Highlights of Early Pulmonary Surfactant: Research from Bench to Clinic. J Pneumon. 2013, 26(4).
    2. Noutsios GT, Ghattas P, Bennett S, and Floros J. Human lung surfactant protein A2 interacts directly with the 14-3-3 regulatory proteins: potential for therapeutic intervention in lung diseases. Atlas of Science. Dec 2015.  http://atlasofscience.org/human-lung-surfactant/
    3. Noutsios GT, Ghattas P, Bennett S, and Floros J. 14-3-3 isoforms bind directly Exon B of the 5’UTR of human surfactant Protein A2 mRNA – correlation with SP-A2 protein expression. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2): L147-57
    4. Noutsios GT, Silveyra P, Bhatti F, and Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. Global Medical Discovery, 2014, ISSN 1929-8536.
    5. Silveyra P, Chroneos ZC, DiAngelo, SL Neal J Thomas, Noutsios GT, Tsotakos N, Howrlylak JA, Umstead TM, and Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in vitro. Exp Lung Res. 2014 40(7):354-66.
    6. Noutsios GT, Silveyra P, Bhatti F, and Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences interacts with 14-3-3; role of cis elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 304(11): L722-35.
    7. Yang W, Ni L, Silveyra P, Wang G, Noutsios GT, Singh A, DiAngelo SL, Sanusi O, Raval M, and Floros J. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. J Mol Biochem. 2013 2: 40-55.
  3. Brucella melitensis
    1. Noutsios GT, Papi RM, Ekateriniadou LV, Minas A, Kyriakidis DA. Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1. Vet Res Commun. 2012 Mar; 36(1):7-20.
    2. G. T. Noutsios, R. M. Papi, L. V. Ekateriniadou, A. Minas and D. A. Kyriakidis. Molecular technique for the diagnosis of brucellosis and differentiation of vaccine strain Rev-1 from the contagious field strains of Brucella melitensis. Volume 9, 2009. Hellenic Medical and Pharmaceutical Review ISSN 1109-7612.
  4. Gut Epithelium Research
    1. Noutsios GT, Raban SS, Grozić A, Yale SH, Rall CJ, Foxx-Orenstein AE, Jurutka PW, Sandrin TR. 16S rRNA Gene Sequencing Affords Insights into Possible Roles of the Gut Microbiome in Irritable Bowel Syndrome (IBS). American Society for Microbiology (ASM), Las Vegas, NV, April 21, 2018
  5. Environmental Microbiology
    1. Tuohy JM, Mueller‐Spitz SR, Albert CM, Scholz‐Ng SE, Wall ME, Noutsios GT, Gutierrez AJ, and Sandrin TR. MALDI-TOF MS Affords Discrimination of Deinococcus aquaticus Isolates Obtained from Diverse Biofilm Habitats. Microbiol. 9:2442. doi: 10.3389/fmicb.2018.02442.

Research Activity

Research Support 

Ongoing:

Arizona Biomedical Research Centre (ABRC)                                  Noutsios (PI)                                     5/8/2018-5/8/2021

Arizona Department of Health Services, Arizona New Investigator Award (AZ NIA), ADHS18-198882: Surfactant Protein A as a new therapeutic in sinusitis. Role: Principal Investigator (PI). Contributions: conception, preliminary data, design, writing, establishing collaborations. Submitted on Nov 30, 2018. Funded on Apr 2, 2018. Amount $225,000 May 2018-May 2021. Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease of the sinus mucosa affecting Arizonans of all ages with staggering health costs. The sinonasal epithelium (SNE) is the physical barrier between the environmental insults and the respiratory system and has immunological functions. Therefore, it is the frontline defense mechanism of the whole respiratory system. Surfactant protein A (SP-A) is a critical innate immune molecule secreted by the airway epithelia and can directly eliminate bacteria. Our data show that SP-A is expressed in the SNE and its levels are significantly changed in bacterial infections, suggesting a role in sinus innate immunity. We hypothesize that SP-A plays a role in susceptibility to CRS and its exogenous administration positively affects CRS. We propose experimental plans that include definition of SP-A role in CRS, identification of endogenous and exogenous factors which come together in a different extent and determine CRS. We will determine the effects of exogenous SP-A in CRS and whether it helps resolve sinusitis. We have 598 tissues from healthy and CRS patients, SP-A humanized transgenic mice and recombinant SP-A to conduct the proposed in vitro and in vivo studies. The use of SP-A as an agent to ameliorate the innate immune responses in the CRS is a new concept and is likely to lead to new horizons in CRS therapeutic regimens.

Courses

Spring 2021
Course Number Course Title
LSC 499 Individualized Instruction

Presentations

Courses

Fall 2019

Course Number                Course Title

BCH392                             Undergraduate Research

Spring 2020

Course Number                Course Title

LSC 493                             Honors Thesis

BCH/CHM 392                  Undergraduate Research

MIC 499                             Individualized Instruction

LSC 592                             Research

 

Fall 2019

Course Number                Course Title

LSC 492                             Honors Directed Study

MIC 495                             Undergraduate Research

MIC 499                             Individualized Instruction

 

Summer 2019

Course Number                Course Title

MIC 499                             Individualized Instruction

 

 

Spring 2019

Course Number                Course Title

LSC 499                             Individualized Instruction

LSC 592                             Research

 

Fall 2018

Course Number                Course Title

LSC 499                             Individualized Instruction

 

Summer 2018

Course Number                Course Title

MIC 499                             Individualized Instruction

LSC 499                             Individualized Instruction

 

Spring  2018

Course Number                Course Title

LSC 499                             Individualized Instruction

 

Other Academic Teaching

  1. Guest Teaching lecture at Arizona State University, Microbiology MIC444, MALDI TOF-MS principles and applications. Oct 24, 2018, CLCC 356, 11.00-11.45am (45 min).
  2. Guest Teaching lecture at Arizona State University, Microbiology MIC443, Prokaryotes, Eukaryotes and Viruses in Respiratory Biomedical Research. Sep 25, 2018, CLCC 246, 10.30-11.45am (75 min).

Invited Seminars

  1. Noutsios GT. Surfactant Protein A as a New Therapeutic in Sinusitis. Arizona State University, School of Mathematical and Natural Sciences Seminar Series, Phoenix, AZ, September 13, 2018, 3-4pm. Invited Lecture.
  2. Noutsios GT. Expression of Surfactant Protein A In Human Nasal Epithelial Cells After Infection With Rhinovirus C In The Presence Of Histamine. 2016 Arizona Physiological Society 9th Annual Meeting, Tucson, AZ, Oct 21-22. Invited Lecture.
  3. Noutsios GT. Differential translational control of lung innate immunity proteins SP-A1 and SP-A2 by 14-3-3 isoforms. Pediatric Departmental Research Series Seminar (DRS). October 15, 2014, 12-1pm. Invited Lecture.
  4. Noutsios GT.Differential translational control of lung innate immunity proteins SP-A1 and SP-A2; cis elements in the 5UTR of SP-A2 interact with 14-3-3, translational initiation proteins and other trans-acting factors. Department of Cellular & Molecular Physiology Seminar December 6, 2013, 12-1pm. Invited Lecture.

Conference Presentations-Lectures

  1. Noutsios GT, Willis AL, Romero EG, Ledford JG, and Chang EH. Novel Role of Surfactant Protein A in Bacterial Sinusitis. American Rhinologic Society 2017 Meeting at COSM San Diego, April 2630. Selected for oral presentation/lecture.
  2. Noutsios GT, Silveyra P, Floros J. Exon B of human Surfactant Protein A2 mRNA alone or within the context of the surrounding sequences binds trans-acting factors that may affect translation. Pediatric Research Day, April 5, 2012 Hershey Lodge, Hershey, PA. Selected for oral presentation/lecture.
  3. G. T. Noutsios, R. M. Papi, L.V. Aikateriniadou, A. Minas and D.A. Kyriakidis Differentiation of Brucella melitensis biotypes by analysis of hypervariable octrameric oligonucleotide fingerprints. 1st Greek Veterinary Congress of Live Stock, Hygiene  Security of Animal Origin Foods and Consumer Protection, March 14-16, 2008, Hotel Hilton, Athens, Greece. Selected for oral presentation/lecture.

Honors/Awards

  1. Western Alliance to Expand Student Opportunities (WAESO) award on undergraduate research proposal entitled, Determine the Gut Microbiome Populations in Irritable Bowel Syndrome Patients (S19UR016/S2019ur0023) received funding at the level of $1,300. Jan 15, 2019.
  2. FY 2019 Merit Award of Arizona State University as an appreciation and recognition of excellent academic contributions and achievements of a valued employee and member of the ASU New College team. Dec 5, 2018.
  3. Arizona New Investigator Award (AZ NIA), Arizona Biomedical Research Centre (ABRC), Arizona Department of Health Services, ADHS18-198882: Surfactant Protein A as a new therapeutic in sinusitis. Role: Principal Investigator (PI). Contributions: conception, preliminary data, design, writing, establishing collaborations. Submitted on Nov 30, 2018. Funded on Apr 2, 2018. Amount $225,000 May 2018-May 2021.
  4. Original Research paper in Biology of Sex Differences (BSD) has been selected as the winner of the 2018 BSD- Organization for the Study of Sex Differences (OSSD) award for best paper published by a member of OSSD in BSD in 2017. Mar 14, 2018.http://blogs.biomedcentral.com/on-biology/2018/06/01/take-a-deep-breath-sex-differences-may-play-a-significant-role-in-the-onset-and-treatment-of-lung-disease/?utm_campaign=shareaholic&utm_medium=facebook&utm_source=socialnetwork
  5. Scholarship from World Hellenic Biomedical Association, to attend the 6th Summer School of the World Hellenic Biomedical Association in Medical & Biosciences Research & Management, May 13 - 21, 2017 in Neo Itilo of Mani Lakonias and Athens, Greece. Ranked among the top-20. Feb 21, 2017.
  6. Bond Bradley Award for Outstanding Postdoctoral Scholar, 2nd place at the Penn State University College of Medicine. February 23, 2016.
  7. Atlas of science has identified publication 14-3-3 isoforms bind directly Exon B of the 5UTR of human surfactant Protein A2 mRNA  correlation with SP-A2 protein expression as being of interest to the broader scientific audience and decided to highlight my article as a laymans summary on their website (http://atlasofscience.org/human-lung-surfactant/). December 9, 2015.
  8. Global Medical Discovery Target Selection team has identified publication: Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences interacts with 14-3-3; role of cis elements and secondary structure as being of special interest to the drug development sector and advancing biomedical research. Therefore, it is featured it on Global Medical Discovery ISSN 1929-8536, January 2014.
  9. Scholarship from the Greek National Institute of Scholarships during the academic year 1998-99 for superb performance.

Editorships

  1. Invited Reviewer on Experimental and Therapeutic Medicine Journal, miR-183 modulates renal fibrosis via targeting SFTPA2 gene, September 7, 2017.
  2. Invited Reviewer on Allergy and Rhinology Journal - manuscript, entitled Impact of Tobacco Smoke on Upper Airway Dendritic Cell Accumulation and Regulation by Sinonasal Epithelial Cells with Dr. Mulligan as corresponding author. Feb 20, 2017.
  3. Invited Reviewer on Respiratory Research Journal - manuscript, entitled Prenatal Tobacco Smoke Exposure Increases Hospitalizations for Bronchiolitis in Infants Respiratory Research with Dr. Vandini as corresponding author. August 4, 2015.
  4. Invited Reviewer on Experimental Lung Research Journal - manuscript, entitled Ectopic expressed miR-203 contributes to Chronic Obstructive Pulmonary Disease via targeting TAK1 and PIK3CA" with Dr Ma as contact author after re-submission to Experimental Lung Research. Final decision reached. July 8, 2015.
  5. Invited Reviewer on Experimental Lung Research Journal - manuscript, entitled Ectopic expressed miR-203 contributes to Chronic Obstructive Pulmonary Disease via targeting TAK1 and PIK3CA with Dr. Ma as contact author. May 17, 2015.
  6. Invited Reviewer on Experimental Lung Research Journal - manuscript, entitled "Surfactant Protein-D does not alter interaction between human primary pulmonary dendritic cell subsets and T-cells" with Dr. Winkler as contact author. January 29, 2014.

Service

Academic Service

  1. Executive Council Member of Penn State Hershey Postdoctoral Society (PSHPS) 2015 – Chair – Treasurer
  2. Executive Council Member of PSHPS 2014  – Chair – Social Events
  3. Executive Council Member of PSHPS 2013 – Chair – Treasurer
  4. Executive Council Member of PSHPS 2012 – Chair – Professional Development

Educational Community Service

  1. Graduate Student Research Forum 2016, Penn State Hershey, College of Medicine, University Conference Center, Hershey, PA, March 3-5, 2016 – Poster Judge.
  2. 2016 Capital Area Science and Engineering Fair 225 Market Street, 2nd Floor Harrisburg, PA 17101. February 25, 2016 – Judge.
  3. Lower Dauphin School District – Middle School - 7th grade life science students - Hannah and Kayla. Answer question about lung cancer and help them put together a small science project. Teacher Mrs Mary Dell. Hummelstown, November 5, 2015.
  4. Delaware Valley Science Fairs (DVSF), The Greater Philadelphia Expo Center, Oaks, PA, April 2, 2014 – Judge.
  5. 2014 Capital Area Science and Engineering Fair 225 Market Street, 2nd Floor Harrisburg, PA 17101. March 13, 2014 – Judge.
  6. Graduate Student Research Forum 2014, Penn State Hershey, College of Medicine, University Conference Center, Hershey, PA, March 6-7, 2014 – Poster Judge.
  7. Summer Undergraduate Research Symposium 2013, Penn State Hershey, College of Medicine, University Conference Center, Hershey, PA, August 1, 2013 – Poster Judge.
  8. Delaware Valley Science Fairs (DVSF), The Greater Philadelphia Expo Center, Oaks, PA, April 3, 2013 – Judge.
  9. 2013 Capital Area Science and Engineering Fair 225 Market Street, 2nd Floor Harrisburg, PA 17101. March 7, 2013 – Judge.
  10. 2012 Summer Undergraduate Research Symposium. Thursday August 2, 2012 University Conference Center (Rooms A-B-C) 9:00 a.m.-4:00 p.m – Evaluator.
  11. 2012 Capital Area Science and Engineering Fair 225 Market Street, 2nd Floor Harrisburg, PA 17101. March 10, 2012 – Judge.

Graduate Faculties / Mentoring History

  1. Supervision and training of research technician of Aleksandra Grozi in standard molecular biology techniques Oct 2018-now.
  2. Supervision and training of undergraduate student Deauna Johnson in Irritable bowel syndrome (IBS) microbiome studies using 16 s rRNA gene sequencing. Aug 2018-now.
  3. Supervision and training of undergraduate student San S. Raban in microbiome processing datasets. Feb 2018-Oct 2018.
  4. Supervision and training of undergraduate student Chad M. Albert in protein extraction and MALDI-TOF techniques. Jan 2017-now.
  5. Supervision and training of undergraduate student Stacy E. ScholzNg in protein extraction, MALDI-TOF techniques and data processing with BioNumerics software. Jan 2017-now.
  6. Supervision and training of undergraduate student Aleksandra Grozi in manuscript preparation and database maintenance. Dec 2017-Aug 2018.
  7. Supervision and training of undergraduate student Anthony J. Gutierrez in scientific data synthesis and manuscript writing. Dec 2017-Nov 2018.
  8. Supervision and training of Research Technician Alexander Kim, BSE to laboratory molecular biology and biochemistry techniques. June 2017-Dec 2017.
  9. Supervision and training of Research Lab Technician Dana Zack, BS in Research Electronic Data Capture (RedCap) and molecular biology techniques. June 2017- Dec 2017.
  10. Supervision and training of undergraduate student Jaeden T. Calton to molecular biology techniques. Aug 2016- Dec 2017.
  11. Supervision and training of neonatologist Faryal Durrani, M.D. to molecular biology techniques. Aug 2015-May 2016.
  12. Training of neonatologist fellow Margaret Gilfillan, M.D. to molecular biology techniques. Aug 2013-Sep 2015.
  13. Supervision of MSR student Paul Ghattas, B.S. Interaction of the 14-3-3 protein family with the 5' UTR of the SP-A1 and SP-A. May 24th-August 2nd, 2013.
  14. Supervision of MSR student Stephanie Bennett, B.S. Interaction of the 14-3-3 family of proteins with the 5 UTR of the SP-A1 and SP-A2 genes. May 24th-August 2nd, 2013.
  15. Supervision of summer student Priyanka Nadar. July-August 2011.

Work History

2017 -              Assistant Research Professor, School of Mathematical and Natural Sciences, Arizona State University.

2016 - 2017     Postdoctoral Research Associate III, Head and Neck Surgery, Department of Otolaryngology, Banner University of Arizona Medical Center

2011 - 2016     Postdoctoral Research Scientist, Department of Pediatrics, College of Medicine, Penn State

2010 - 2011     Head of Research and Development at FarmaChem S.A.

2009 - 2010     Application Specialist, Millipore, Greece.

2006 - 2009     Researcher, Reinforcement Program of Human Research Manpower, Immobilization of biomolecules with antigenic properties in polymeric substrates for the production of diagnostic system and examination of the biotypes or Brucella melitensis, Biochemical Laboratory, Chemical Department, Aristotle University of Thessaloniki

2004 - 2005     Medical Scientist Liaison, P. Zafiropoulos S.A.

2000 - 2000     Intern, General Hellenic Chemical Department

 

Industry Positions

2010 - 2011     Head of Research and Development at FarmaChem S.A.

Performed and/or assisted in various phases of R&D and formulation development activities. Conducted research for scientific evidence through a variety of resources, including internet to support the beneficial effects of the ingredients in the public health products. Assisted in creating supplement fact panels, procuring substantiation, and maintaining the R&D files. Assisted in development of crop-protection products, collecting all necessary documentation, including research papers, proofreading of advertising material, and maintaining the records. Ensured promised turn-around times on analyses were met. Kept abreast of current trends, practices, developments, and regulatory changes, which would impact products or formulations.